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Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.

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Cover of Molecular Biology of the Cell

Molecular Biology of the Cell. 4th edition.

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Figure 23-25. Loss of contact inhibition in cell culture.

Figure 23-25Loss of contact inhibition in cell culture

Most normal cells stop proliferating once they have carpeted the dish with a single layer of cells: proliferation seems to depend on contact with the dish, and to be inhibited by contacts with other cells. Cancer cells, in contrast, usually disregard these restraints and continue to grow, so that they pile up on top of one another.

From: Finding the Cancer-Critical Genes

Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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